Novel Ethylene Cross-bridged Tetra- and Penta- Azamacrocycles

Abstract

Ethylene cross-bridged tetraazamacrocyclic ligands have gained common use in applications where transition metal complexes must withstand harsh aqueous conditions, such as oxidation catalysis, biomedical imaging, and bioinorganic medicinal compounds. We wish to add additional members to this ligand family by (1) using sterically-hindered parent tetraazamacrocyles; and (2) expanding the macrocyclic parent to pentaazamacrocycles. Here, we present strategies for producing both new kinds of ethylene cross-bridged azamacrocycles and their transition metal complexes.