Evaluation of Systematic Review Utilization in the Development of OB-GYN Randomized Controlled Trials

Abstract

The issue of research waste has been raised due to the fact that 85% of funding for biomedical research has been improperly utilized. A prominent issue is the frequency of randomized controlled trials (RCTs) being conducted without prior consultation of existing support, such as systematic reviews (SRs). Meticulous monitoring is necessary to ensure that clinical recommendations are being made with confidence in high-quality biomedical practices. The aim of this study was to survey OB-GYN journals to analyze their published articles for citation of SR for justification of conducting the RCT. We conducted a search of PubMed for RCTs published between 2014 and 2017 in the top 10 OB-GYN journals. Studies were evaluated to determine the number of SRs cited in the introduction, methods, and discussion. We further analyzed whether the SR was cited verbatim or indirectly, number of participants, type of intervention being studied, funding source, type of trial, and how the outcome was perceived. Of the 720 articles from our initial search, 458 (63.61%) met inclusion criteria. Of the 458 included studies, 279 (60.92%) cited an SR in the introduction, 34 (7.42%) in the methods, and 207 (45.2%) in the discussion as justification for conducting the study. A large portion of the RCTs being published in clinical OB-GYN journals are not citing SRs as justification for conducting their studies, which may be leading to an increase in research waste.