Small molecule design strategies for probing structure-activity relationships: bacterial virulence modulation via CpxRA, the total synthesis of Picrasma alkaloids, and coronavirus main protease inhibitors

dc.contributor.advisor	Singh, Shanteri
dc.contributor.advisor	Duerfeldt, Adam
dc.contributor.author	Gardner, Jessica Jeanora Hayes
dc.contributor.committeeMember	Cichewicz, Robert
dc.contributor.committeeMember	O'Rear, Edgar
dc.contributor.committeeMember	Glatzhofer, Daniel
dc.date.accessioned	2022-05-10T16:05:16Z
dc.date.available	2022-05-10T16:05:16Z
dc.date.issued	2022-05-13
dc.date.manuscript	2022
dc.description.abstract	The overall aim of this work is to contribute to molecular design strategies for early lead development while probing structure-activity relationships via the design and synthesis of small molecules. This dissertation will tell three distinct stories: (1) exploitation of CpxRA as a target for virulence modulation in Gram-negative bacteria, (2) work towards the total synthesis of Picrasidine natural product family members, and (3) the rational design and synthesis of SARS-CoV-2 main protease inhibitors.	en_US
dc.identifier.uri	https://hdl.handle.net/11244/335667
dc.language	en_US	en_US
dc.subject	Virulence	en_US
dc.subject	Protease Inhibitors	en_US
dc.subject	Natural Products	en_US
dc.subject	Synthetic Chemistry	en_US
dc.thesis.degree	Ph.D.	en_US
dc.title	Small molecule design strategies for probing structure-activity relationships: bacterial virulence modulation via CpxRA, the total synthesis of Picrasma alkaloids, and coronavirus main protease inhibitors	en_US
ou.group	Dodge Family College of Arts and Sciences:: Department of Chemistry and Biochemistry	en_US