The Design, Synthesis of Novel Ligands for the Optical Purification of ?-Amino Acids

Abstract

Research associated with the application of a-amino acids has been a topic of interest in various scientific fields ranging from agriculture to pharmacy due to the versatility of these relatively simple compounds. One of the hurdles that has slowed progress in these areas has been the access to these compounds in enantiomerically pure form. Therefore the focus of the investigations to be presented will be the development of efficient methods for increasing access to these materials. Specifically, the rational design and preparation of an optically active ligand system will be presented. Additionally, the application of this system for the preparation of a-amino acids will be demonstrated through a dynamic resolution process.